1yv0 Summary


Crystal structure of skeletal muscle troponin in the Ca2+-free state

The structure was published by Vinogradova, M.V., Stone, D.B., Malanina, G.G., et al., Cooke, R., Mendelson, R.A., and Fletterick, R.J., in 2005 in a paper entitled "Ca2+-regulated structural changes in troponin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 7.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Troponin T, fast skeletal muscle isoforms, Troponin I, fast skeletal muscle, and Troponin C, skeletal muscle.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
T Troponin T, fast skeletal muscle isoforms P12620 (157-263) (TNNT3_CHICK)search Gallus gallussearch < 90% 107 79%
I Troponin I, fast skeletal muscle P68246 (2-138) (TNNI2_CHICK)search Gallus gallussearch 99% 137 84%
C Troponin C, skeletal muscle P02588 (2-163) (TNNC2_CHICK)search Gallus gallussearch 98% 162 91%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P12620 (157 - 263) Troponin T, fast skeletal muscle isoforms Gallus gallus
P68246 (2 - 138) Troponin I, fast skeletal muscle Gallus gallus
P02588 (2 - 163) Troponin C, skeletal muscle Gallus gallus

Chain Structural classification (SCOP) Sequence family (Pfam)
T Troponin Tsearch Troponinsearch
I (P68246) Troponin Isearch PF00992: Troponinsearch
C (P02588) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
T (P12620) troponin complexsearch regulation of muscle contractionsearch regulation of striated muscle contractionsearch
I (P68246) troponin complexsearch
C (P02588) troponin complexsearch calcium ion bindingsearch metal ion bindingsearch actin bindingsearch skeletal muscle contractionsearch

Chain InterPro annotation
T Troponinsearch Troponin Tsearch Troponin T, fast skeletal musclesearch
I Troponinsearch
C EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch