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Cathepsin K complexed with a constrained ketoamide inhibitor

X-ray diffraction
2.3Å resolution
PDB entry 1yt7 coloured by chain, front view.
PDB entry 1yt7 coloured by chain, side view.
PDB entry 1yt7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin K
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Multimeric state: monomeric
Accessible surface area: 9750.48 Å2
Buried surface area: 1276.26 Å2
Dissociation area: 451.02 Å2
Dissociation energy (ΔGdiss): 1.64 kcal/mol
Dissociation entropy (TΔSdiss): 5.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154996

Macromolecules

Cathepsin K
Chain: A
Length: 215 amino acids
Theoretical weight: 23.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43235 (Residues: 115-329; Coverage: 69%)
Gene names: CTSK, CTSO, CTSO2
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
SCOP: Papain-like
Cathepsin K in PDB entry 1yt7, assembly 1, front view.
Cathepsin K in PDB entry 1yt7, assembly 1, side view.
Cathepsin K in PDB entry 1yt7, assembly 1, top view.
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