1ysa Summary

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THE GCN4 BASIC REGION LEUCINE ZIPPER BINDS DNA AS A DIMER OF UNINTERRUPTED ALPHA HELICES: CRYSTAL STRUCTURE OF THE PROTEIN-DNA COMPLEX

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Ellenberger, T.E., Brandl, C.J., Struhl, K., and Harrison, S.C., in 1992 in a paper entitled "The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*TP*TP*CP*CP*TP*AP*TP*GP*AP*CP*TP*CP*AP*TP*CP*CP*A P*GP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*CP*TP*GP*GP*AP*TP*GP*AP*GP*TP*CP*AP*TP*A P*GP*GP*A)-3'), and PROTEIN (GCN4).

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C PROTEIN (GCN4) P03069 (226-281) (GCN4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 58 98%
D PROTEIN (GCN4) P03069 (226-281) (GCN4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 58 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03069 (226 - 281) PROTEIN (GCN4) Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C, D Leucine zipper domainsearch Classic Zinc Fingersearch bZIP transcription factorsearch

Chain ID Biological process (GO) Molecular function (GO)
C, D (P03069) regulation of transcription, DNA-templatedsearch sequence-specific DNA bindingsearch nucleic acid bindingsearch sequence-specific DNA binding transcription factor activitysearch

Chain InterPro annotation
C, D Basic-leucine zipper domainsearch