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Crystal structure of human PNP complexed with MESG

X-ray diffraction
2.8Å resolution
PDB entry 1yry coloured by chain, front view.
PDB entry 1yry coloured by chain, side view.
PDB entry 1yry coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: monomeric
Accessible surface area: 12037.66 Å2
Buried surface area: 1279.31 Å2
Dissociation area: 355.48 Å2
Dissociation energy (ΔGdiss): 3.03 kcal/mol
Dissociation entropy (TΔSdiss): 4.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132559
Assembly 2
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo trimer
Accessible surface area: 28473.68 Å2
Buried surface area: 11465.89 Å2
Dissociation area: 3,884.27 Å2
Dissociation energy (ΔGdiss): 50.35 kcal/mol
Dissociation entropy (TΔSdiss): 27.71 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-132560

Macromolecules

Purine nucleoside phosphorylase
Chain: E
Length: 289 amino acids
Theoretical weight: 32.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00491 (Residues: 1-289; Coverage: 100%)
Gene names: NP, PNP
Pfam: Phosphorylase superfamily
InterPro:
CATH: Nucleoside phosphorylase domain
SCOP: Purine and uridine phosphorylases
Purine nucleoside phosphorylase in PDB entry 1yry, assembly 1, front view.
Purine nucleoside phosphorylase in PDB entry 1yry, assembly 1, side view.
Purine nucleoside phosphorylase in PDB entry 1yry, assembly 1, top view.
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