1yru Summary


Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride

The structure was published by Guo, Q., Shen, Y., Lee, Y.S., Gibbs, C.S., Mrksich, M., and Tang, W.J., in 2005 in a paper entitled "Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bifunctional hemolysin-adenylate cyclase and Calmodulin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Bifunctional hemolysin-adenylate cyclase P0DKX7 (1-364) (CYAA_BORPE)search Bordetella pertussis Tohama Isearch < 90% 364 96%
B Calmodulin P62158 (76-149) (CALM_HUMAN)search Homo sapienssearch 97% 74 93%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P0DKX7 (1 - 364) Bifunctional hemolysin-adenylate cyclase Bordetella pertussis
P62158 (76 - 149) Calmodulin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
B (P62158) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P0DKX7) calcium- and calmodulin-responsive adenylate cyclase activitysearch pathogenesissearch extracellular regionsearch
B (P62158) calcium ion bindingsearch

Chain InterPro annotation
A Anthrax toxin, edema factor, centralsearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch