1yrt Summary

pdbe.org/1yrt
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Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin

The structure was published by Guo, Q., Shen, Y., Lee, Y.S., Gibbs, C.S., Mrksich, M., and Tang, W.J., in 2005 in a paper entitled "Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bifunctional hemolysin-adenylate cyclase and Calmodulin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Bifunctional hemolysin-adenylate cyclase P0DKX7 (1-364) (CYAA_BORPE)search Bordetella pertussis Tohama Isearch < 90% 364 96%
B Calmodulin P62158 (76-149) (CALM_HUMAN)search Homo sapienssearch 97% 74 93%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P0DKX7 (1 - 364) Bifunctional hemolysin-adenylate cyclase Bordetella pertussis
P62158 (76 - 149) Calmodulin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A
B (P62158) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P0DKX7) extracellular regionsearch pathogenesissearch calcium- and calmodulin-responsive adenylate cyclase activitysearch
B (P62158) calcium ion bindingsearch

Chain InterPro annotation
A Anthrax toxin, edema factor, centralsearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch