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PDBe Entry: 1yrs 
Crystal structure of KSP in complex with inhibitor 1
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CELL CYCLE
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X-RAY DIFFRACTION
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Resolution: 2.5 Å, R-factor: 25.0%, Free R-factor: 31.0%, Spacegroup: P 21 21 21
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12/04/2005, deposition: 04/02/2005, last revision: 24/02/2009
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Cox, C.D.; Breslin, M.J.; Mariano, B.J.; Coleman, P.J.; Buser, C.A.; Walsh, E.S.; Hamilton, K.; Kohl, N.E.; Torrent, M.; Yan, Y.; Kuo, L.C.; Hartman, G.D.
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Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
BIOORG.MED.CHEM.LETT. vol:15, pag:2041-2045 (2005) [PubMed ID 15808464 ]
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CELL CYCLE
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Homo sapiens(human) 9606(A B)
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Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP-5) (Kinesin-like protein 1) P52732 (A B)
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A, B
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| A, B |
Kinesin-like protein KIF11 |
Protein |
P52732 (KIF11_HUMAN)
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368 |
89% |
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| B, A |
MAGNESIUM ION |
MG
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| A, B |
ADENOSINE-5'-DIPHOSPHATE |
ADP
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| A, B |
3-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL |
L47
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