1yr5 Summary


1.7-A structure of calmodulin bound to a peptide from DAP kinase

A publication describing this structure is not available. The depositing authors are Kursula, P.search; Vahokoski, J.search; Wilmanns, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely calmodulin and 19-mer from Death-associated protein kinase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A calmodulin P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 98%
B 19-mer from Death-associated protein kinase 1 P53355 (302-320) (DAPK1_HUMAN)search Homo sapienssearch < 90% 19 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (2 - 149) calmodulin Homo sapiens
P53355 (302 - 320) 19-mer from Death-associated protein kinase 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P62158) calcium channel complexsearch spindle polesearch extracellular regionsearch nucleussearch nucleoplasmsearch cytoplasmsearch centrosomesearch cytosolsearch cytoskeletonsearch spindle microtubulesearch plasma membranesearch sarcomeresearch growth conesearch vesiclesearch neuron projectionsearch extracellular vesicular exosomesearch response to amphetaminesearch regulation of heart ratesearch platelet degranulationsearch detection of calcium ionsearch carbohydrate metabolic processsearch glycogen catabolic processsearch glucose metabolic processsearch muscle contractionsearch signal transductionsearch epidermal growth factor receptor signaling pathwaysearch G-protein coupled receptor signaling pathwaysearch activation of adenylate cyclase activitysearch activation of phospholipase C activitysearch synaptic transmissionsearch blood coagulationsearch phototransduction, visible lightsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of peptidyl-threonine phosphorylationsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch rhodopsin mediated signaling pathwaysearch calcium-mediated signalingsearch substantia nigra developmentsearch regulation of rhodopsin mediated signaling pathwaysearch platelet activationsearch positive regulation of cyclic nucleotide metabolic processsearch positive regulation of protein autophosphorylationsearch regulation of cytokinesissearch positive regulation of phosphoprotein phosphatase activitysearch positive regulation of protein dephosphorylationsearch Fc-epsilon receptor signaling pathwaysearch inositol phosphate metabolic processsearch small molecule metabolic processsearch innate immune responsesearch nitric oxide metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch regulation of nitric-oxide synthase activitysearch positive regulation of nitric-oxide synthase activitysearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch response to corticosteronesearch response to calcium ionsearch regulation of cardiac muscle contractionsearch regulation of ryanodine-sensitive calcium-release channel activitysearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch membrane organizationsearch positive regulation of protein serine/threonine kinase activitysearch regulation of high voltage-gated calcium channel activitysearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch calcium ion bindingsearch protein bindingsearch adenylate cyclase bindingsearch protein kinase bindingsearch protein domain specific bindingsearch enzyme regulator activitysearch nitric-oxide synthase regulator activitysearch titin bindingsearch type 3 metabotropic glutamate receptor bindingsearch thioesterase bindingsearch N-terminal myristoylation domain bindingsearch phospholipase bindingsearch protein serine/threonine kinase activator activitysearch phosphatidylinositol 3-kinase bindingsearch ion channel bindingsearch metal ion bindingsearch protein N-terminus bindingsearch calcium-dependent protein bindingsearch nitric-oxide synthase bindingsearch protein phosphatase activator activitysearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch