1yqj Summary


Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor

The structure was published by Tamayo, N., Liao, L., Goldberg, M., et al., Jang, G., Hungate, R., and Dominguez, C., in 2005 in a paper entitled "Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 355 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q16539) protein phosphorylationsearch toll-like receptor 5 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch positive regulation of myotube differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch regulation of transcription from RNA polymerase II promotersearch peptidyl-serine phosphorylationsearch glucose metabolic processsearch signal transduction in response to DNA damagesearch transcription, DNA-templatedsearch Ras protein signal transductionsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch stress-activated MAPK cascadesearch myoblast differentiation involved in skeletal muscle regenerationsearch response to muramyl dipeptidesearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of myoblast fusionsearch gene expressionsearch positive regulation of reactive oxygen species metabolic processsearch cell surface receptor signaling pathwaysearch positive regulation of myoblast differentiationsearch toll-like receptor 4 signaling pathwaysearch cellular response to DNA damage stimulussearch regulation of sequence-specific DNA binding transcription factor activitysearch MyD88-independent toll-like receptor signaling pathwaysearch platelet activationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of transcription, DNA-templatedsearch cellular response to lipopolysaccharidesearch skeletal muscle tissue developmentsearch DNA damage checkpointsearch cell morphogenesissearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor signaling pathwaysearch cellular response to ionizing radiationsearch activation of MAPK activitysearch toll-like receptor 3 signaling pathwaysearch osteoclast differentiationsearch intracellular signal transductionsearch signal transductionsearch mRNA metabolic processsearch RNA metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch cartilage condensationsearch TRIF-dependent toll-like receptor signaling pathwaysearch angiogenesissearch toll-like receptor 9 signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch response to stresssearch apoptotic processsearch response to lipopolysaccharidesearch chemotaxissearch cellular component movementsearch fatty acid oxidationsearch striated muscle cell differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch p38MAPK cascadesearch phosphorylationsearch blood coagulationsearch toll-like receptor 10 signaling pathwaysearch muscle cell differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch chondrocyte differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch stress-induced premature senescencesearch innate immune responsesearch positive regulation of protein import into nucleussearch nucleoplasmsearch cytosolsearch spindle polesearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch cytoplasmsearch cellsearch protein bindingsearch NFAT protein bindingsearch MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch transferase activitysearch nucleotide bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch