1yp0 Summary


Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a SHP peptide motif

The structure was published by Li, Y., Choi, M., Cavey, G., et al., Bingham, N., Kliewer, S., and Xu, H., in 2005 in a paper entitled "Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely nuclear receptor subfamily 5, group A, member 1 and Nuclear receptor subfamily 0, group B, member 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A nuclear receptor subfamily 5, group A, member 1 P33242 (223-461) (STF1_MOUSE)search Mus musculussearch < 90% 239 100%
B Nuclear receptor subfamily 0, group B, member 2 P97947 (17-28) (NR0B2_RAT)search Rattus norvegicussearch < 90% 12 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P33242 (223 - 461) nuclear receptor subfamily 5, group A, member 1 Mus musculus
P97947 (17 - 28) Nuclear receptor subfamily 0, group B, member 2

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P33242) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch