1yon Summary


Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate

The structure was published by Ciulli, A., Lobley, C.M., Tuck, K.L., Smith, A.G., Blundell, T.L., and Abell, C., in 2007 in a paper entitled "pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 2-dehydropantoate 2-reductase. This molecule has the UniProt identifier P0A9J4 (PANE_ECOLI)search. The sample contained 303 residues which is < 90% of the natural sequence. Out of 303 residues 291 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 2-dehydropantoate 2-reductase Not available
Escherichia colisearch Not available 303 96%

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A () oxidation-reduction processsearch pantothenate biosynthetic processsearch pantothenate biosynthetic process from valinesearch oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorsearch coenzyme bindingsearch oxidoreductase activitysearch 2-dehydropantoate 2-reductase activitysearch NADP bindingsearch cytoplasmsearch

Chain InterPro annotation
A Ketopantoate reductase ApbA/PanEsearch 6-phosphogluconate dehydrogenase, C-terminal-likesearch Dehydrogenase, multihelicalsearch Ketopantoate reductase, N-terminal domainsearch Ketopantoate reductase, C-terminal domainsearch NAD(P)-binding domainsearch