1yom Summary

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Crystal structure of Src kinase domain in complex with Purvalanol A

The structure was published by Breitenlechner, C.B., Kairies, N.A., Honold, K., et al., Schaefer, W., Huber, R., and Engh, R.A., in 2005 in a paper entitled "Crystal structures of active SRC kinase domain complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase Src.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P12931 (254-536) (SRC_HUMAN)search Homo sapienssearch 100% 283 92%
B Proto-oncogene tyrosine-protein kinase Src P12931 (254-536) (SRC_HUMAN)search Homo sapienssearch 100% 283 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (254 - 536) Proto-oncogene tyrosine-protein kinase Src Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P12931) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF07714: Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P12931) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch