1yol Summary

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Crystal structure of Src kinase domain in complex with CGP77675

The structure was published by Breitenlechner, C.B., Kairies, N.A., Honold, K., et al., Schaefer, W., Huber, R., and Engh, R.A., in 2005 in a paper entitled "Crystal structures of active SRC kinase domain complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase Src.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P12931 (254-536) (SRC_HUMAN)search Homo sapienssearch 100% 283 90%
B Proto-oncogene tyrosine-protein kinase Src P12931 (254-536) (SRC_HUMAN)search Homo sapienssearch 100% 283 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (254 - 536) Proto-oncogene tyrosine-protein kinase Src Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P12931) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF07714: Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P12931) protein phosphorylationsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch ATP bindingsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch