1yok Summary


crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol

The structure was published by Krylova, I.N., Sablin, E.P., Moore, J., et al., Fletterick, R.J., Willson, T.M., and Ingraham, H.A., in 2005 in a paper entitled "Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Orphan nuclear receptor NR5A2 and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Orphan nuclear receptor NR5A2 O00482 (300-541) (NR5A2_HUMAN)search Homo sapienssearch < 90% 256 92%
B Nuclear receptor coactivator 2 Q15596 (740-753) (NCOA2_HUMAN)search Homo sapienssearch < 90% 14 100%
C Nuclear receptor coactivator 2 Q15596 (740-753) (NCOA2_HUMAN)search Homo sapienssearch < 90% 14 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O00482 (300 - 541) Orphan nuclear receptor NR5A2 Homo sapiens
Q15596 (740 - 753) Nuclear receptor coactivator 2

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B, C

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (O00482) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B, C