› 1yoj

X-ray diffraction
1.95Å resolution

Crystal structure of Src kinase domain

Released:
DOI: 10.2210/pdb1yoj/pdb
PDB entry 1yoj coloured by chain, front view.
PDB entry 1yoj coloured by chain, side view.
PDB entry 1yoj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of active SRC kinase domain complexes.
Breitenlechner CB, Kairies NA, Honold K, Scheiblich S, Koll H, Greiter E, Koch S, Schäfer W, Huber R, Engh RA
J Mol Biol 353 222-31 (2005)
PMID: 16168436

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 283 amino acids
Theoretical weight: 32.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12931 (Residues: 254-536; Coverage: 53%)
Gene names: SRC, SRC1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 41.867Å b: 62.542Å c: 73.902Å
α: 100.52° β: 88.88° γ: 89.99°
R-values:
R R work R free
0.216 0.214 0.258
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling.
Monteiro et al. (2008)
3 more

11 mentions without citation

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity.
Lee et al. (2010)
10 more