1yo2 Summary

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Proton Transfer from His200 in Human Carbonic Anhydrase II

The structure was published by Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., and Silverman, D.N., in 2005 in a paper entitled "Proton transfer in a Thr200His mutant of human carbonic anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (1-259) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 259) Carbonic anhydrase II Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch response to zinc ionsearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch bicarbonate transportsearch small molecule metabolic processsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch kidney developmentsearch cellular response to fluid shear stresssearch response to estrogensearch response to pHsearch positive regulation of osteoclast differentiationsearch one-carbon metabolic processsearch plasma membranesearch extracellular vesicular exosomesearch cytoplasmsearch microvillussearch cytosolsearch axonsearch myelin sheathsearch apical part of cellsearch membranesearch basolateral plasma membranesearch extracellular spacesearch protein bindingsearch metal ion bindingsearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch