1yo1 Summary


Proton Transfer from His200 in Human Carbonic Anhydrase II

The structure was published by Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., and Silverman, D.N., in 2005 in a paper entitled "Proton transfer in a Thr200His mutant of human carbonic anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase II Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch one-carbon metabolic processsearch positive regulation of bone resorptionsearch small molecule metabolic processsearch positive regulation of dipeptide transmembrane transportsearch response to estrogensearch regulation of chloride transportsearch bicarbonate transportsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch kidney developmentsearch response to steroid hormonesearch secretionsearch response to pHsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch cytosolsearch basolateral plasma membranesearch apical part of cellsearch microvillussearch plasma membranesearch extracellular vesicular exosomesearch cytoplasmsearch membranesearch extracellular spacesearch axonsearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch