1ynt Summary

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Structure of the immunodominant epitope displayed by the surface antigen 1 (SAG1) of Toxoplasma gondii complexed to a monoclonal antibody

The structure was published by Graille, M., Stura, E.A., Bossus, M., et al., Rolland, D., Le Du, M.H., and Ducancel, F., in 2005 in a paper entitled "Crystal structure of the complex between the monomeric form of Toxoplasma gondii surface antigen 1 (SAG1) and a monoclonal antibody that mimics the human immune response" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This entry contains 9 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heteroheptamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 4F11E12 Fab variable light chain region Not available
Mus musculussearch Not available 213 100%
C 4F11E12 Fab variable light chain region Not available
Mus musculussearch Not available 213 100%
B 4F11E12 Fab variable heavy chain region Not available
Mus musculussearch Not available 218 100%
D 4F11E12 Fab variable heavy chain region Not available
Mus musculussearch Not available 218 100%
E protein L Q51918 (476-536) (Q51918_FINMA)search Finegoldia magnasearch < 90% 61 100%
F Major surface antigen p30 P13664 (50-303) (P30_TOXGO)search Toxoplasma gondiisearch 100% 254 99%
G Major surface antigen p30 P13664 (50-303) (P30_TOXGO)search Toxoplasma gondiisearch 100% 254 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q51918 (476 - 536) protein L Finegoldia magna ATCC 29328
P13664 (50 - 303) Major surface antigen p30 Toxoplasma gondii

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C Immunoglobulinssearch
B, D C1 set domains (antibody constant domain-like)search Immunoglobulinssearch
E Immunoglobulin-binding domainssearch Ubiquitin-like (UB roll)search Protein L b1 domainsearch
F, G (P13664) Major surface antigen p30, SAG1search Immunoglobulin-likesearch PF04092: SRS domainsearch

Chain ID Cellular component (GO)
F, G (P13664) membranesearch

Chain InterPro annotation
A, C Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
B, D Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
E Protein L, Ig light chain-bindingsearch
F, G SRS domainsearch