1ymt Summary

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Mouse SF-1 LBD

The structure was published by Krylova, I.N., Sablin, E.P., Moore, J., et al., Fletterick, R.J., Willson, T.M., and Ingraham, H.A., in 2005 in a paper entitled "Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.2 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Steroidogenic factor 1 and Nuclear receptor 0B2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroidogenic factor 1 P33242 (219-462) (STF1_MOUSE)search Mus musculussearch < 90% 246 95%
B Nuclear receptor 0B2 Q62227 (17-30) (NR0B2_MOUSE)search Mus musculussearch < 90% 14 71%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P33242 (219 - 462) Steroidogenic factor 1 Mus musculus
Q62227 (17 - 30) Nuclear receptor 0B2

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P33242) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B