1ymm Summary

pdbe.org/1ymm
spacer

TCR/HLA-DR2b/MBP-peptide complex

The structure was published by Hahn, M., Nicholson, M.J., Pyrdol, J., and Wucherpfennig, K.W., in 2005 in a paper entitled "Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This entry contains 6 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DR alpha chain P01903 (26-216) (DRA_HUMAN)search Homo sapienssearch < 90% 191 95%
B HLA class II histocompatibility antigen, DR beta chain P01911 (30-227) (2B1F_HUMAN)search Homo sapienssearch < 90% 198 89%
C MBP peptide P02686 (217-240) (MBP_HUMAN)search Homo sapienssearch < 90% 23 60%
D T cell receptor alpha chain P01848 (2-96) (TCA_HUMAN)search Homo sapienssearch < 90% 207 46%
E T-cell receptor beta chain P01850 (1-131) (TRBC1_HUMAN)search Homo sapienssearch < 90% 249 98%


This entry contains 5 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 216) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P01911 (30 - 227) HLA class II histocompatibility antigen, DR beta chain Homo sapiens
P02686 (217 - 240) MBP peptide
P01848 (2 - 96) T cell receptor alpha chain Homo sapiens
P01850 (1 - 131) T-cell receptor beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C Myelin basic proteinsearch
D V set domains (antibody variable domain-like)search Immunoglobulinssearch Domain of unknown function (DUF1968)search
E V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch Immunoglobulin C1-set domainsearch

Chain ID Cellular component (GO) Biological process (GO)
A (P01903) membranesearch MHC class II protein complexsearch antigen processing and presentationsearch immune responsesearch
B (P01911) MHC class II protein complexsearch membranesearch antigen processing and presentationsearch immune responsesearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C Myelin basic proteinsearch
D Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch Domain of unknown function DUF1968search
E Immunoglobulin C1-setsearch Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch