1ym7 Summary

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G Protein-Coupled Receptor Kinase 2 (GRK2)

The structure was published by Lodowski, D.T., Barnhill, J.F., Pyskadlo, R.M., Ghirlando, R., Sterne-Marr, R., and Tesmer, J.J.G., in 2005 in a paper entitled "The role of Gbetagamma and domain interfaces in the activation of G protein-coupled receptor kinase 2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Beta-adrenergic receptor kinase 1.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Beta-adrenergic receptor kinase 1 P21146 (1-689) (ARBK1_BOVIN)search Bos taurussearch 97% 689 88%
B Beta-adrenergic receptor kinase 1 P21146 (1-689) (ARBK1_BOVIN)search Bos taurussearch 97% 689 88%
C Beta-adrenergic receptor kinase 1 P21146 (1-689) (ARBK1_BOVIN)search Bos taurussearch 97% 689 88%
D Beta-adrenergic receptor kinase 1 P21146 (1-689) (ARBK1_BOVIN)search Bos taurussearch 97% 689 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P21146 (1 - 689) Beta-adrenergic receptor kinase 1 Bos taurus

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D (P21146) Regulator of G-protein signaling, RGSsearch, Pleckstrin-homology domain (PH domain)search, Protein kinases, catalytic subunitsearch PF00069: Protein kinase domainsearch, PF00169: PH domainsearch, PF00615: Regulator of G protein signaling domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P21146) termination of G-protein coupled receptor signaling pathwaysearch desensitization of G-protein coupled receptor protein signaling pathwaysearch phosphorylationsearch cardiac muscle contractionsearch negative regulation of striated muscle contractionsearch protein phosphorylationsearch tachykinin receptor signaling pathwaysearch receptor internalizationsearch signal transductionsearch G-protein coupled acetylcholine receptor signaling pathwaysearch regulation of the force of heart contractionsearch heart developmentsearch peptidyl-serine phosphorylationsearch G-protein coupled receptor internalizationsearch negative regulation of the force of heart contraction by chemical signalsearch G-protein coupled receptor signaling pathwaysearch intracellular protein transportsearch peptidyl-threonine phosphorylationsearch regulation of signal transductionsearch G-protein coupled receptor kinase activitysearch nucleotide bindingsearch protein bindingsearch Edg-2 lysophosphatidic acid receptor bindingsearch transferase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch alpha-2A adrenergic receptor bindingsearch beta-adrenergic receptor kinase activitysearch cytosolsearch membranesearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D GPCR kinasesearch Regulator of G protein signalling domainsearch Protein kinase domainsearch AGC-kinase, C-terminalsearch Pleckstrin homology domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Pleckstrin homology-like domainsearch Regulator of G protein signalling superfamilysearch Protein kinase, ATP binding sitesearch