› 1ym7

X-ray diffraction
4.5Å resolution

G Protein-Coupled Receptor Kinase 2 (GRK2)

Released:
DOI: 10.2210/pdb1ym7/pdb
PDB entry 1ym7 coloured by chain, front view.
PDB entry 1ym7 coloured by chain, side view.
PDB entry 1ym7 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.
Lodowski DT, Barnhill JF, Pyskadlo RM, Ghirlando R, Sterne-Marr R, Tesmer JJ
Biochemistry 44 6958-70 (2005)
PMID: 15865441

Function and Biology Details

Reaction catalysed: 
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-adrenergic receptor kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 689 amino acids
Theoretical weight: 79.75 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21146 (Residues: 1-689; Coverage: 100%)
Gene names: ADRBK1, GRK2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P2
Unit cell:
a: 115.162Å b: 82.156Å c: 218.795Å
α: 90° β: 95.57° γ: 90°
R-values:
R R work R free
0.226 0.224 0.279
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.
Gurevich et al. (2012)
8 more

5 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
4 more