› 1ylk

X-ray diffraction
2Å resolution

Crystal Structure of Rv1284 from Mycobacterium tuberculosis in Complex with Thiocyanate

Released:
DOI: 10.2210/pdb1ylk/pdb
PDB entry 1ylk coloured by chain, front view.
PDB entry 1ylk coloured by chain, side view.
PDB entry 1ylk coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.
Suarez Covarrubias A, Larsson AM, Högbom M, Lindberg J, Bergfors T, Björkelid C, Mowbray SL, Unge T, Jones TA
J Biol Chem 280 18782-9 (2005)
PMID: 15753099

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161988 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-carbonic anhydrase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 172 amino acids
Theoretical weight: 19.26 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPJ7 (Residues: 2-163; Coverage: 99%)
Gene names: MTCY373.03, Rv1284, canA, mtcA1
Sequence domains: Carbonic anhydrase
Structure domains: Carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand SCN 5 x SCN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: F222
Unit cell:
a: 100.164Å b: 154.074Å c: 156.943Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.226
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.
Supuran CT. (2008)
11 more

8 mentions without citation

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors.
Karioti et al. (2016)
7 more