1ykr Summary

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Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor

The structure was published by Hamdouchi, C., Zhong, B., Mendoza, J., et al., Watkins, S.A., Zhang, F., and Brooks, H.B., in 2005 in a paper entitled "Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 298 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch cyclin bindingsearch protein serine/threonine kinase activitysearch metal ion bindingsearch nucleotide bindingsearch histone kinase activitysearch protein phosphorylationsearch peptidyl-serine phosphorylationsearch histone phosphorylationsearch cell cyclesearch G2/M transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell divisionsearch G1/S transition of mitotic cell cyclesearch DNA repairsearch positive regulation of transcription, DNA-templatedsearch positive regulation of DNA-dependent DNA replication initiationsearch centrosome duplicationsearch meiotic nuclear divisionsearch cellular response to DNA damage stimulussearch Ras protein signal transductionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic nuclear divisionsearch blood coagulationsearch mitotic G1 DNA damage checkpointsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of cell proliferationsearch regulation of gene silencingsearch cellular response to nitric oxidesearch meiotic cell cyclesearch DNA replicationsearch phosphorylationsearch potassium ion transportsearch mitotic cell cyclesearch nucleoplasmsearch cytoskeletonsearch cytosolsearch X chromosomesearch nucleussearch transcription factor complexsearch endosomesearch cytoplasmsearch Y chromosomesearch centrosomesearch Cajal bodysearch microtubule organizing centersearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch condensed chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch