1yio Summary

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Crystallographic structure of response regulator StyR from Pseudomonas fluorescens

The structure was published by Milani, M., Leoni, L., Rampioni, G., Zennaro, E., Ascenzi, P., and Bolognesi, M., in 2005 in a paper entitled "An Active-like Structure in the Unphosphorylated StyR Response Regulator Suggests a Phosphorylation- Dependent Allosteric Activation Mechanism" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of response regulatory protein. This molecule has the UniProt identifier O30989 (O30989_PSEFL)search. The sample contained 208 residues which is 100% of the natural sequence. Out of 208 residues 198 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A response regulatory protein O30989 (1-208) (O30989_PSEFL)search Pseudomonas fluorescenssearch 100% 208 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O30989 (1 - 208) response regulatory protein Pseudomonas fluorescens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (O30989) GerE-like (LuxR/UhpA family of transcriptional regulators)search, CheY-relatedsearch Rossmann foldsearch, "winged helix" repressor DNA binding domainsearch PF00072: Response regulator receiver domainsearch, PF00196: Bacterial regulatory proteins, luxR familysearch

Chain ID Biological process (GO) Molecular function (GO)
A (O30989) phosphorelay signal transduction systemsearch transcription, DNA-templatedsearch regulation of transcription, DNA-templatedsearch DNA bindingsearch metal ion bindingsearch sequence-specific DNA binding transcription factor activitysearch

Chain InterPro annotation
A Transcription regulator LuxR, C-terminalsearch Signal transduction response regulator, receiver domainsearch CheY-like superfamilysearch Winged helix-turn-helix DNA-binding domainsearch