1yi6 Summary

pdbe.org/1yi6
spacer

C-term tail segment of human tyrosine kinase (258-533)

The structure was published by Fleury, D., Sarubbi, E., Courjaud, A., Guitton, J.D., and Ducruix, A., in in a paper entitled "Structure of the unphosphorylated C-terminal tail segment of the SRC kinase and its role in SRC activity regulation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase Src.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P12931 (261-536) (SRC_HUMAN)search Homo sapienssearch 100% 276 100%
B Proto-oncogene tyrosine-protein kinase Src P12931 (261-536) (SRC_HUMAN)search Homo sapienssearch 100% 276 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (261 - 536) Proto-oncogene tyrosine-protein kinase Src Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P12931) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF07714: Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P12931) protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch