Crystal Structure of Pim-1 bound to LY294002
The structure was published by Jacobs, M.D., Black, J., Futer, O., et al., Hare, B., Fleming, M., and Saxena, K., in 2005 in a paper entitled "Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase Pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN). The sample contained 273 residues which is < 90% of the natural sequence. Out of 273 residues 268 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: