1yi3 Summary

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Crystal Structure of Pim-1 bound to LY294002

The structure was published by Jacobs, M.D., Black, J., Futer, O., et al., Hare, B., Fleming, M., and Saxena, K., in 2005 in a paper entitled "Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase Pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN)search. The sample contained 273 residues which is < 90% of the natural sequence. Out of 273 residues 268 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene serine/threonine-protein kinase Pim-1 P11309 (124-396) (PIM1_HUMAN)search Homo sapienssearch < 90% 273 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (124 - 396) Proto-oncogene serine/threonine-protein kinase Pim-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch