1yh9 Summary

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T-to-T(High) quaternary transitions in human hemoglobin: HbA OXY (2MM IHP, 20% PEG) (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) protein bindingsearch metal ion bindingsearch heme bindingsearch haptoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxidation-reduction processsearch extracellular vesicular exosomesearch blood microparticlesearch cytosolsearch hemoglobin complexsearch extracellular regionsearch membranesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch
B, D (P68871) heme bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxidation-reduction processsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch renal absorptionsearch regulation of blood pressuresearch oxygen transportsearch platelet aggregationsearch small molecule metabolic processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch blood coagulationsearch transportsearch nitric oxide transportsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch cytosolsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch