1yff Summary

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STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL

A publication describing this structure is not available. The depositing authors are Patskovska, L.search; Patskovsky, Y.search; Hirsch, R.E.search; Almo, S.C.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C, E, G (P69905) iron ion bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch membranesearch cytosolic small ribosomal subunitsearch cytosolsearch endocytic vesicle lumensearch bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch oxidation-reduction processsearch protein heterooligomerizationsearch
B, D, F, H (P68871) protein bindingsearch oxygen transporter activitysearch heme bindingsearch hemoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch extracellular vesicular exosomesearch regulation of blood pressuresearch nitric oxide transportsearch response to hydrogen peroxidesearch bicarbonate transportsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch oxygen transportsearch small molecule metabolic processsearch receptor-mediated endocytosissearch oxidation-reduction processsearch protein heterooligomerizationsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch blood coagulationsearch renal absorptionsearch transportsearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch