1yff Summary

pdbe.org/1yff
spacer

STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL

A publication describing this structure is not available. The depositing authors are Patskovska, L.search; Patskovsky, Y.search; Hirsch, R.E.search; Almo, S.C.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C, E, G (P69905) heme bindingsearch oxygen bindingsearch iron ion bindingsearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular exosomesearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch oxygen transportsearch protein heterooligomerizationsearch bicarbonate transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch
B, D, F, H (P68871) heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin bindingsearch metal ion bindingsearch blood microparticlesearch extracellular exosomesearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular regionsearch haptoglobin-hemoglobin complexsearch oxygen transportsearch protein heterooligomerizationsearch bicarbonate transportsearch positive regulation of cell deathsearch regulation of blood pressuresearch renal absorptionsearch regulation of blood vessel sizesearch blood coagulationsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch transportsearch nitric oxide transportsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch small molecule metabolic processsearch platelet aggregationsearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch