1yeu Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.12 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch oxygen bindingsearch iron ion bindingsearch peroxidase activitysearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular exosomesearch blood microparticlesearch membranesearch cytosolic small ribosomal subunitsearch oxygen transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch receptor-mediated endocytosissearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch
B, D (P68871) heme bindingsearch iron ion bindingsearch hemoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch cytosolsearch hemoglobin complexsearch blood microparticlesearch extracellular exosomesearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch oxygen transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch regulation of blood vessel sizesearch nitric oxide transportsearch renal absorptionsearch protein heterooligomerizationsearch blood coagulationsearch transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch regulation of blood pressuresearch receptor-mediated endocytosissearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch