1yeu Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.12 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch hydrogen peroxide catabolic processsearch transportsearch oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch protein heterooligomerizationsearch oxidation-reduction processsearch
B, D (P68871) heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch iron ion bindingsearch hemoglobin bindingsearch metal ion bindingsearch haptoglobin bindingsearch cytosolsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch receptor-mediated endocytosissearch oxygen transportsearch platelet aggregationsearch transportsearch small molecule metabolic processsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch renal absorptionsearch nitric oxide transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch bicarbonate transportsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch blood coagulationsearch response to hydrogen peroxidesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch