1yeu Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.12 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch protein bindingsearch peroxidase activitysearch iron ion bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen bindingsearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch transportsearch
B, D (P68871) iron ion bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch oxygen bindingsearch peroxidase activitysearch hemoglobin bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolsearch bicarbonate transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch nitric oxide transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch oxygen transportsearch protein heterooligomerizationsearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch transportsearch regulation of blood vessel sizesearch regulation of blood pressuresearch small molecule metabolic processsearch oxidation-reduction processsearch blood coagulationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch