1yeq Summary

pdbe.org/1yeq
spacer

T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y OXY (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxidation-reduction processsearch transportsearch receptor-mediated endocytosissearch small molecule metabolic processsearch response to hydrogen peroxidesearch bicarbonate transportsearch protein heterooligomerizationsearch oxygen transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch protein bindingsearch haptoglobin bindingsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch iron ion bindingsearch oxygen transporter activitysearch metal ion bindingsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch membranesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch blood microparticlesearch cytosolsearch
B, D (P68871) oxygen transportsearch platelet aggregationsearch response to hydrogen peroxidesearch bicarbonate transportsearch small molecule metabolic processsearch transportsearch blood coagulationsearch renal absorptionsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch nitric oxide transportsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch oxygen transporter activitysearch protein bindingsearch hemoglobin bindingsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch iron ion bindingsearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch