1ye2 Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaY35F oxy (2MM IHP, 20% PEG) (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch iron ion bindingsearch metal ion bindingsearch oxygen transporter activitysearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxygen transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch transportsearch oxidation-reduction processsearch extracellular regionsearch blood microparticlesearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch
B, D (P68871) protein bindingsearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin bindingsearch heme bindingsearch oxygen transporter activitysearch iron ion bindingsearch oxygen transportsearch small molecule metabolic processsearch blood coagulationsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch bicarbonate transportsearch transportsearch hydrogen peroxide catabolic processsearch renal absorptionsearch regulation of blood pressuresearch positive regulation of cell deathsearch oxidation-reduction processsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch nitric oxide transportsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch hemoglobin complexsearch extracellular regionsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch