1ydd Summary

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STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II

The structure was published by Nair, S.K., Krebs, J.F., Christianson, D.W., and Fierke, C.A., in 1995 in a paper entitled "Structural basis of inhibitor affinity to variants of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch lyase activitysearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch extracellular vesicular exosomesearch cytosolsearch axonsearch plasma membranesearch cytoplasmsearch microvillussearch extracellular spacesearch apical part of cellsearch basolateral plasma membranesearch membranesearch myelin sheathsearch positive regulation of bone resorptionsearch response to zinc ionsearch one-carbon metabolic processsearch kidney developmentsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch small molecule metabolic processsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to pHsearch angiotensin-activated signaling pathwaysearch secretionsearch response to steroid hormonesearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch response to organic substancesearch response to estrogensearch odontogenesis of dentin-containing toothsearch regulation of anion transportsearch positive regulation of synaptic transmission, GABAergicsearch regulation of chloride transportsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch