1ydb Summary

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STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II

The structure was published by Nair, S.K., Krebs, J.F., Christianson, D.W., and Fierke, C.A., in 1995 in a paper entitled "Structural basis of inhibitor affinity to variants of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytosolsearch cytoplasmsearch apical part of cellsearch axonsearch membranesearch extracellular spacesearch plasma membranesearch basolateral plasma membranesearch microvillussearch response to steroid hormone stimulussearch response to stresssearch one-carbon metabolic processsearch morphogenesis of an epitheliumsearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch bicarbonate transportsearch angiotensin-mediated signaling pathwaysearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch kidney developmentsearch response to zinc ionsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch carbon dioxide transportsearch secretionsearch response to estrogen stimulussearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch response to pHsearch response to organic substancesearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2/13search Carbonic anhydrase, alpha-classsearch