1ycs Summary

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P53-53BP2 COMPLEX

The structure was published by Gorina, S. and Pavletich, N.P., in 1996 in a paper entitled "Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely P53 and 53BP2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A P53 P04637 (94-292) (P53_HUMAN)search Homo sapienssearch < 90% 199 95%
B 53BP2 Q13625 (892-925) (ASPP2_HUMAN)search ,
Q13625 (926-1126) (ASPP2_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
239 80%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04637 (94 - 292) P53 Homo sapiens
Q13625 (892 - 925) 53BP2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A p53 DNA-binding domain-likesearch Immunoglobulin-likesearch P53 DNA-binding domainsearch
B Ankyrin repeatsearch, SH3-domainsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch, SH3 Domainssearch SH3 domainsearch, Ankyrin repeatsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P04637) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch transcription regulatory region DNA bindingsearch nucleussearch regulation of transcription, DNA-dependentsearch apoptotic processsearch

Chain InterPro annotation
A p53 tumour suppressor familysearch p53-like transcription factor, DNA-bindingsearch p53, DNA-binding domainsearch p53/RUNT-type transcription factor, DNA-binding domainsearch
B Src homology-3 domainsearch Ankyrin repeatsearch Spectrin alpha chain, SH3 domainsearch Ankyrin repeat-containing domainsearch