› 1yb1

X-ray diffraction
1.95Å resolution

Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

Released:
DOI: 10.2210/pdb1yb1/pdb
PDB entry 1yb1 coloured by chain, front view.
PDB entry 1yb1 coloured by chain, side view.
PDB entry 1yb1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lukacik P, Bunkoczi G, Kavanagh K, Ng S, von Delft F, Bray J, Edwards A, Arrowsmith C, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-185477 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estradiol 17-beta-dehydrogenase 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 272 amino acids
Theoretical weight: 29.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NBQ5 (Residues: 15-275; Coverage: 91%)
Gene names: DHRS8, HSD17B11, PAN1B, PSEC0029, SDR16C2, UNQ207/PRO233
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

4 bound ligands:
Ligand CL 6 x CL
Ligand SO4 2 x SO4
Ligand AOI 2 x AOI
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P41212
Unit cell:
a: 110.939Å b: 110.939Å c: 118.013Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.192
Expression system: Escherichia coli

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