1ya5 Summary


Crystal structure of the titin domains z1z2 in complex with telethonin

The structure was published by Zou, P., Pinotsis, N., Lange, S., et al., Mayans, O.M., Gautel, M., and Wilmanns, M., in 2006 in a paper entitled "Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.445 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely N2B-TITIN ISOFORM and TELETHONIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A N2B-TITIN ISOFORM Q8WZ42 (1-196) (TITIN_HUMAN)search Homo sapienssearch < 90% 201 98%
B N2B-TITIN ISOFORM Q8WZ42 (1-196) (TITIN_HUMAN)search Homo sapienssearch < 90% 201 98%
T TELETHONIN O15273 (1-90) (TELT_HUMAN)search Homo sapienssearch 100% 90 98%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8WZ42 (1 - 196) N2B-TITIN ISOFORM Homo sapiens
O15273 (1 - 90) TELETHONIN Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Immunoglobulinssearch Immunoglobulin I-set domainsearch
T (O15273) titin domain likesearch PF09470: Telethonin proteinsearch
Chain InterPro annotation
A, B Immunoglobulin subtype 2search Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin I-setsearch Immunoglobulin-like foldsearch
T Telethoninsearch Titin-like domainsearch