1y8y Summary


Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor

The structure was published by Williamson, D.S., Parratt, M.J., Bower, J.F., et al., Robertson, A., Surgenor, A.E., and Torrance, C.J., in 2005 in a paper entitled "Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.996 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 291 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch cell cyclesearch meiotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic G2 phasesearch G2/M transition of mitotic cell cyclesearch cell divisionsearch G1/S transition of mitotic cell cyclesearch histone phosphorylationsearch blood coagulationsearch mitotic nuclear divisionsearch regulation of gene silencingsearch potassium ion transportsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch DNA replicationsearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to nitric oxidesearch positive regulation of transcription, DNA-templatedsearch centrosome duplicationsearch phosphorylationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch positive regulation of cell proliferationsearch DNA repairsearch Ras protein signal transductionsearch mitotic cell cyclesearch cellular response to DNA damage stimulussearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch metal ion bindingsearch kinase activitysearch histone kinase activitysearch transferase activitysearch cyclin bindingsearch cytoskeletonsearch nucleoplasmsearch cytosolsearch microtubule organizing centersearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch cytoplasmsearch centrosomesearch endosomesearch X chromosomesearch transcription factor complexsearch Y chromosomesearch nucleussearch Cajal bodysearch condensed chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch