1y8y Summary


Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor

The structure was published by Williamson, D.S., Parratt, M.J., Bower, J.F., et al., Robertson, A., Surgenor, A.E., and Torrance, C.J., in 2005 in a paper entitled "Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.996 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 291 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch protein bindingsearch cyclin bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch metal ion bindingsearch nucleotide bindingsearch histone kinase activitysearch protein phosphorylationsearch DNA replicationsearch G1/S transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch DNA repairsearch cell cyclesearch centrosome duplicationsearch mitotic cell cyclesearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch potassium ion transportsearch cellular response to DNA damage stimulussearch meiotic nuclear divisionsearch cell divisionsearch blood coagulationsearch positive regulation of transcription, DNA-templatedsearch mitotic nuclear divisionsearch cellular response to nitric oxidesearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch regulation of gene silencingsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch phosphorylationsearch Ras protein signal transductionsearch positive regulation of DNA-dependent DNA replication initiationsearch nucleoplasmsearch Cajal bodysearch condensed chromosomesearch endosomesearch cytosolsearch centrosomesearch Y chromosomesearch cytoplasmsearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch nucleussearch X chromosomesearch transcription factor complexsearch microtubule organizing centersearch cytoskeletonsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch