1y85 Summary

pdbe.org/1y85
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PDB entry 1y85 (supersedes 1axf)

T-To-T(High) quaternary transitions in human hemoglobin: desHIS146beta deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.13 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-146) (HBB_HUMAN)search Homo sapienssearch 98% 145 100%
D Hemoglobin beta chain P68871 (2-146) (HBB_HUMAN)search Homo sapienssearch 98% 145 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 146) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch iron ion bindingsearch metal ion bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch oxygen transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch protein heterooligomerizationsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch blood microparticlesearch extracellular vesicular exosomesearch extracellular regionsearch membranesearch cytosolsearch hemoglobin complexsearch endocytic vesicle lumensearch
B, D (P68871) oxygen bindingsearch heme bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen transportsearch transportsearch nitric oxide transportsearch regulation of blood pressuresearch renal absorptionsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch regulation of blood vessel sizesearch receptor-mediated endocytosissearch platelet aggregationsearch blood coagulationsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch cytosolsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch