1y7z Summary

pdbe.org/1y7z
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T-To-T(High) quaternary transitions in human hemoglobin: betaN108A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.98 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch membranesearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch protein heterooligomerizationsearch oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch small molecule metabolic processsearch
B, D (P68871) endocytic vesicle lumensearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch heme bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch protein bindingsearch hemoglobin bindingsearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch oxygen transportsearch regulation of blood vessel sizesearch transportsearch nitric oxide transportsearch bicarbonate transportsearch regulation of blood pressuresearch renal absorptionsearch blood coagulationsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch platelet aggregationsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch