1y7g Summary

pdbe.org/1y7g
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T-To-T(high) quaternary transitions in human hemoglobin: betaN102A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch bicarbonate transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch transportsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch membranesearch
B, D (P68871) iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transporter activitysearch protein bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch heme bindingsearch oxygen transportsearch renal absorptionsearch transportsearch oxidation-reduction processsearch platelet aggregationsearch bicarbonate transportsearch regulation of blood pressuresearch small molecule metabolic processsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch blood coagulationsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch