1y6w Summary

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Trapped intermediate of calmodulin

The structure was published by Grabarek, Z., in 2005 in a paper entitled "Structure of a Trapped Intermediate of Calmodulin: Calcium Regulation of EF-hand Proteins from a New Perspective." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Calmodulin. This molecule has the UniProt identifier P62158 (CALM_HUMAN)search. The sample contained 148 residues which is 99% of the natural sequence. Out of 148 residues 145 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62158 (2 - 149) Calmodulin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P62158) Fc-epsilon receptor signaling pathwaysearch signal transductionsearch neurotrophin TRK receptor signaling pathwaysearch calcium-mediated signalingsearch synaptic transmissionsearch carbohydrate metabolic processsearch regulation of high voltage-gated calcium channel activitysearch regulation of cytokinesissearch inositol phosphate metabolic processsearch positive regulation of protein serine/threonine kinase activitysearch innate immune responsesearch activation of phospholipase C activitysearch small molecule metabolic processsearch regulation of heart ratesearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch rhodopsin mediated signaling pathwaysearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch positive regulation of protein autophosphorylationsearch substantia nigra developmentsearch response to corticosteronesearch positive regulation of cyclic nucleotide metabolic processsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch platelet degranulationsearch muscle contractionsearch epidermal growth factor receptor signaling pathwaysearch positive regulation of protein dephosphorylationsearch glycogen catabolic processsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch positive regulation of nitric-oxide synthase activitysearch positive regulation of peptidyl-threonine phosphorylationsearch nitric oxide metabolic processsearch membrane organizationsearch positive regulation of phosphoprotein phosphatase activitysearch fibroblast growth factor receptor signaling pathwaysearch negative regulation of peptidyl-threonine phosphorylationsearch regulation of rhodopsin mediated signaling pathwaysearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch G-protein coupled receptor signaling pathwaysearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch regulation of nitric-oxide synthase activitysearch glucose metabolic processsearch phototransduction, visible lightsearch response to amphetaminesearch activation of adenylate cyclase activitysearch regulation of cardiac muscle contractionsearch blood coagulationsearch platelet activationsearch response to calcium ionsearch detection of calcium ionsearch spindle polesearch cytoplasmsearch extracellular vesicular exosomesearch cytosolsearch plasma membranesearch cytoskeletonsearch nucleussearch calcium channel complexsearch nucleoplasmsearch spindlesearch spindle microtubulesearch vesiclesearch growth conesearch extracellular regionsearch sarcomeresearch centrosomesearch neuron projectionsearch calcium ion bindingsearch protein bindingsearch adenylate cyclase bindingsearch protein kinase bindingsearch enzyme regulator activitysearch protein phosphatase activator activitysearch ion channel bindingsearch type 3 metabotropic glutamate receptor bindingsearch phospholipase bindingsearch titin bindingsearch metal ion bindingsearch protein N-terminus bindingsearch protein domain specific bindingsearch nitric-oxide synthase bindingsearch nitric-oxide synthase regulator activitysearch N-terminal myristoylation domain bindingsearch phosphatidylinositol 3-kinase bindingsearch calcium-dependent protein bindingsearch protein serine/threonine kinase activator activitysearch thioesterase bindingsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch