1y6w Summary


Trapped intermediate of calmodulin

The structure was published by Grabarek, Z., in 2005 in a paper entitled "Structure of a Trapped Intermediate of Calmodulin: Calcium Regulation of EF-hand Proteins from a New Perspective." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Calmodulin. This molecule has the UniProt identifier P62158 (CALM_HUMAN)search. The sample contained 148 residues which is 99% of the natural sequence. Out of 148 residues 145 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62158 (2 - 149) Calmodulin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62158) calcium ion bindingsearch protein bindingsearch phospholipase bindingsearch adenylate cyclase bindingsearch N-terminal myristoylation domain bindingsearch protein domain specific bindingsearch ion channel bindingsearch type 3 metabotropic glutamate receptor bindingsearch calcium-dependent protein bindingsearch titin bindingsearch nitric-oxide synthase regulator activitysearch metal ion bindingsearch enzyme regulator activitysearch phosphatidylinositol 3-kinase bindingsearch protein N-terminus bindingsearch protein phosphatase activator activitysearch nitric-oxide synthase bindingsearch thioesterase bindingsearch cytosolsearch cytoplasmsearch spindle microtubulesearch nucleoplasmsearch growth conesearch calcium channel complexsearch plasma membranesearch spindlesearch cytoskeletonsearch extracellular vesicular exosomesearch centrosomesearch extracellular regionsearch sarcomeresearch neuron projectionsearch nucleussearch spindle polesearch positive regulation of cyclic nucleotide metabolic processsearch substantia nigra developmentsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch positive regulation of nitric-oxide synthase activitysearch platelet degranulationsearch muscle contractionsearch positive regulation of protein dephosphorylationsearch epidermal growth factor receptor signaling pathwaysearch membrane organizationsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch nitric oxide metabolic processsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of phosphoprotein phosphatase activitysearch glycogen catabolic processsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch blood coagulationsearch platelet activationsearch regulation of nitric-oxide synthase activitysearch regulation of cardiac muscle contractionsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch activation of adenylate cyclase activitysearch response to corticosteronesearch glucose metabolic processsearch phototransduction, visible lightsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of rhodopsin mediated signaling pathwaysearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch G-protein coupled receptor signaling pathwaysearch inositol phosphate metabolic processsearch synaptic transmissionsearch calcium-mediated signalingsearch rhodopsin mediated signaling pathwaysearch innate immune responsesearch regulation of heart ratesearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch activation of phospholipase C activitysearch small molecule metabolic processsearch Fc-epsilon receptor signaling pathwaysearch regulation of high voltage-gated calcium channel activitysearch regulation of cytokinesissearch carbohydrate metabolic processsearch signal transductionsearch neurotrophin TRK receptor signaling pathwaysearch response to calcium ionsearch detection of calcium ionsearch response to amphetaminesearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch