› 1y6w

X-ray diffraction
2.4Å resolution

Trapped intermediate of calmodulin

Released:
DOI: 10.2210/pdb1y6w/pdb
PDB entry 1y6w coloured by chain, front view.
PDB entry 1y6w coloured by chain, side view.
PDB entry 1y6w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a trapped intermediate of calmodulin: calcium regulation of EF-hand proteins from a new perspective.
Grabarek Z
J Mol Biol 346 1351-66 (2005)
PMID: 15713486

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin-1 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 17.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0DP23 (Residues: 2-149; Coverage: 99%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand MPD 1 x MPD
Ligand TBU 1 x TBU
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P43212
Unit cell:
a: 109.875Å b: 109.875Å c: 42.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.238
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Handling calcium signaling: Arabidopsis CaMs and CMLs.
McCormack et al. (2005)
4 more

4 mentions without citation

Structural and functional diversity of Entamoeba histolytica calcium-binding proteins.
Kumar et al. (2020)
3 more