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PDB entry 1y5m

The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes

The structure was published by Zhang, J., Osslund, T.D., Plant, M.H., et al., Xiong, F., Delaney, J.M., and Jordan, S.R., in 2005 in a paper entitled "Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Corticosteroid 11-beta-dehydrogenase, isozyme 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Corticosteroid 11-beta-dehydrogenase, isozyme 1 P50172 (24-291) (DHI1_MOUSE)search Mus musculussearch 90% 276 96%
B Corticosteroid 11-beta-dehydrogenase, isozyme 1 P50172 (24-291) (DHI1_MOUSE)search Mus musculussearch 90% 276 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P50172 (24 - 291) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P50172) Tyrosine-dependent oxidoreductasessearch NAD(P)-binding Rossmann-like Domainsearch short chain dehydrogenasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P50172) 11-beta-hydroxysteroid dehydrogenase [nad(p)] activitysearch, Oxidoreductase activitysearch, 11-beta-hydroxysteroid dehydrogenase (nadp+) activitysearch Endoplasmic reticulumsearch, Endoplasmic reticulum membranesearch, Membranesearch, Integral to membranesearch Lipid metabolic processsearch, Steroid metabolic processsearch, Lung developmentsearch, Oxidation-reduction processsearch

Chain InterPro annotation
A, B Short-chain dehydrogenase/reductase SDRsearch, Glucose/ribitol dehydrogenasesearch, NAD(P)-binding domainsearch, Short-chain dehydrogenase/reductase, conserved sitesearch