1y5j Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaH97A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.03 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch heme bindingsearch oxygen bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch membranesearch oxidation-reduction processsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch
B, D (P68871) oxygen transporter activitysearch peroxidase activitysearch protein bindingsearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch metal ion bindingsearch extracellular vesicular exosomesearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch oxygen transportsearch renal absorptionsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch blood coagulationsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch platelet aggregationsearch nitric oxide transportsearch transportsearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch