1y57 Summary

pdbe.org/1y57
spacer

Structure of unphosphorylated c-Src in complex with an inhibitor

The structure was published by Cowan-Jacob, S.W., Fendrich, G., Manley, P.W., et al., Fabbro, D., Liebetanz, J., and Meyer, T., in 2005 in a paper entitled "The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.91 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase Src. This molecule has the UniProt identifier P12931 (SRC_HUMAN)search. The sample contained 452 residues which is < 90% of the natural sequence. Out of 452 residues 448 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P12931 (86-536) (SRC_HUMAN)search Homo sapienssearch 100% 452 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (86 - 536) Proto-oncogene tyrosine-protein kinase Src Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P12931) SH3-domainsearch, SH2 domainsearch, Protein kinases, catalytic subunitsearch SH3 Domainssearch, SHC Adaptor Proteinsearch, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00017: SH2 domainsearch, PF00018: SH3 domainsearch, PF07714: Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P12931) ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch SH2 domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch SH3 domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch