1y4v Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaC93A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.84 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin complexsearch extracellular regionsearch membranesearch extracellular exosomesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch blood microparticlesearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch oxidation-reduction processsearch
B, D (P68871) iron ion bindingsearch protein bindingsearch heme bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch endocytic vesicle lumensearch extracellular regionsearch extracellular exosomesearch hemoglobin complexsearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch oxygen transportsearch oxidation-reduction processsearch bicarbonate transportsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch nitric oxide transportsearch platelet aggregationsearch receptor-mediated endocytosissearch transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch blood coagulationsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch renal absorptionsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch