1y4v Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaC93A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.84 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch oxygen bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch oxidation-reduction processsearch extracellular vesicular exosomesearch membranesearch extracellular regionsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch
B, D (P68871) heme bindingsearch oxygen bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch nitric oxide transportsearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch blood coagulationsearch positive regulation of cell deathsearch protein heterooligomerizationsearch transportsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch renal absorptionsearch regulation of blood pressuresearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch endocytic vesicle lumensearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch