1y4r Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch metal ion bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin complexsearch cytosolsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch extracellular exosomesearch endocytic vesicle lumensearch membranesearch blood microparticlesearch oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch transportsearch
B, D (P68871) iron ion bindingsearch oxygen bindingsearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch extracellular regionsearch blood microparticlesearch hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch endocytic vesicle lumensearch oxygen transportsearch bicarbonate transportsearch platelet aggregationsearch blood coagulationsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch renal absorptionsearch oxidation-reduction processsearch positive regulation of cell deathsearch transportsearch nitric oxide transportsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch