1y4r Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch protein bindingsearch iron ion bindingsearch metal ion bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch transportsearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch membranesearch blood microparticlesearch
B, D (P68871) protein bindingsearch hemoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch platelet aggregationsearch bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch regulation of blood pressuresearch blood coagulationsearch renal absorptionsearch nitric oxide transportsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch transportsearch extracellular regionsearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch