1y4r Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch extracellular regionsearch blood microparticlesearch membranesearch extracellular vesicular exosomesearch cytosolsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch receptor-mediated endocytosissearch transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxygen transportsearch small molecule metabolic processsearch oxidation-reduction processsearch bicarbonate transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch
B, D (P68871) protein bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch hemoglobin complexsearch extracellular regionsearch blood microparticlesearch positive regulation of cell deathsearch nitric oxide transportsearch regulation of blood vessel sizesearch bicarbonate transportsearch transportsearch oxygen transportsearch renal absorptionsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch blood coagulationsearch platelet aggregationsearch oxidation-reduction processsearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch