1y4p Summary

pdbe.org/1y4p
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PDB entry 1y4p (supersedes 1a0y)

T-To-T(high) quaternary transitions in human hemoglobin: betaW37E deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.98 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch metal ion bindingsearch heme bindingsearch oxygen transporter activitysearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch membranesearch cytosolic small ribosomal subunitsearch bicarbonate transportsearch receptor-mediated endocytosissearch oxygen transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch transportsearch
B, D (P68871) oxygen bindingsearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch iron ion bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch regulation of blood vessel sizesearch oxygen transportsearch bicarbonate transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch transportsearch regulation of blood pressuresearch protein heterooligomerizationsearch positive regulation of cell deathsearch nitric oxide transportsearch receptor-mediated endocytosissearch oxidation-reduction processsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch blood coagulationsearch platelet aggregationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch