1y4g Summary

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PDB entry 1y4g (supersedes 1a0x)

T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.91 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch positive regulation of cell deathsearch transportsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular regionsearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch heme bindingsearch oxygen transporter activitysearch metal ion bindingsearch
B, D (P68871) response to hydrogen peroxidesearch oxygen transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch small molecule metabolic processsearch oxidation-reduction processsearch regulation of blood pressuresearch blood coagulationsearch bicarbonate transportsearch renal absorptionsearch regulation of blood vessel sizesearch platelet aggregationsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch transportsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch heme bindingsearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch peroxidase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch