1y4g Summary

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PDB entry 1y4g (supersedes 1a0x)

T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.91 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch small molecule metabolic processsearch response to hydrogen peroxidesearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch protein bindingsearch peroxidase activitysearch oxygen bindingsearch metal ion bindingsearch oxygen transporter activitysearch extracellular regionsearch cytosolsearch membranesearch extracellular vesicular exosomesearch blood microparticlesearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) hydrogen peroxide catabolic processsearch renal absorptionsearch platelet aggregationsearch regulation of blood vessel sizesearch nitric oxide transportsearch regulation of blood pressuresearch oxygen transportsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch blood coagulationsearch receptor-mediated endocytosissearch transportsearch oxidation-reduction processsearch protein bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch heme bindingsearch iron ion bindingsearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch extracellular vesicular exosomesearch blood microparticlesearch hemoglobin complexsearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch